A ghrelin receptor antagonist
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JMV3002

Item No. 10012699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-1-[4-[(2,4-dimethoxyphenyl)methyl]-5-(2-phenyylethyl)-4H-1,2,4-triazol-3-yl]-2-(1H-indol-3-yl)ethyl]-2-pyridinecarboxamide
CAS Number
925239-03-8
Molecular Formula
C35H34N6O3
Formula Weight
586.7
Purity
≥98%
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
270 nm
SMILES
COc1ccc(Cn2c(CCc3ccccc3)nnc2C(NC(=O)c2ccccn2)Cc2c[nH]c3ccccc23)c(OC)c1
InChi Code
InChI=1S/C35H34N6O3/c1-43-27-17-16-25(32(21-27)44-2)23-41-33(18-15-24-10-4-3-5-11-24)39-40-34(41)31(38-35(42)30-14-8-9-19-36-30)20-26-22-37-29-13-7-6-12-28(26)29/h3-14,16-17,19,21-22,31,37H,15,18,20,23H2,1-2H3,(H,38,42)/t31-/m1/s1
InChi Key
UMGBPWZCCHVQAY-WJOKGBTCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 µg

    $66

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    500 µg

    $285

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    1 mg

    $503

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    5 mg

    $2,103

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro.1 At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats.1 JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moulin, A., Demange, L., Ryan, J., et al. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. J. Med. Chem. 51, 689-693 (2008).