A CYP3A metabolite of midazolam
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Analytical Standard(s)
39954α-hydroxy Midazolam (CRM)
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α-hydroxy Midazolam

Item No. 10385

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol
CAS Number
59468-90-5
Synonyms
  • 1’-hydroxy Midazolam
  • Ro 21-6347
Molecular Formula
C18H13ClFN3O
Formula Weight
341.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/ml
λmax
217 nm
SMILES
FC1=CC=CC=C1C2=NCC3=CN=C(CO)N3C4=C2C=C(Cl)C=C4
InChi Code
InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
InChi Key
QHSMEGADRFZVNE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    α-hydroxy Midazolam is the major metabolite of the anesthetic, midazolam. It is produced rapidly by the actions of hepatic cytochrome P450 3A and has been shown to be equipotent to midazolam.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perloff, M.D., von Moltke, L.L., Court, M.H., et al. Midazolam and triazolam biotransformation in mouse and human liver microsomes: Relative contribution of CYP3A and CYP2C isoforms. J. Pharmacol. Exp. Ther. 292(2), 618-628 (2000).

    Product Citations

    Negoro, R., Tasaka, M., Deguchi, S., et al. Generation of HepG2 cells with high expression of multiple drug-metabolizing enzymes for drug discovery research using a PITCh system. Cells 11(10), 1677 (2022).