A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
Related Products
Parent Compound(s)
16193Midazolam 19391Midazolam (CRM)
Research Tool(s)
10385α-hydroxy Midazolam
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α-hydroxy Midazolam (CRM)

A 100 µg/ml or 1 mg/ml solution in methanol

Item No. 39954

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 1'-hydroxy Midazolam
  • Ro 21-6347
Technical Information
Formal Name
8-chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-1-methanol
CAS Number
59468-90-5
Molecular Formula
C18H13ClFN3O
Formula Weight
341.8
Formulation
A 100 µg/ml or 1 mg/ml solution in methanol
SMILES
FC1=CC=CC=C1C2=NCC3=CN=C(CO)N3C4=C2C=C(Cl)C=C4
InChi Code
InChI=1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2
InChi Key
QHSMEGADRFZVNE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

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    Product Description

    α-hydroxy Midazolam (CRM) (Item No. 39954) is a certified reference material categorized as a benzodiazepine.1 α-hydroxy Midazolam is an active metabolite of midazolam (Item Nos. 19391 | 16193).1,2 This product is intended for research and forensic applications. This product is also available as a general research tool (Item No. 10385).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Perloff, M.D., von Moltke, L.L., Court, M.H., et al. Midazolam and triazolam biotransformation in mouse and human liver microsomes: Relative contribution of CYP3A and CYP2C isoforms. J. Pharmacol. Exp. Ther. 292(2), 618-628 (2000).

    2. Bauer, T.M., Ritz, R., Haberthür, C., et al. Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 346(8968), 145-147 (1995).