A PARP inhibitor
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3-amino Benzamide

Item No. 10397

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-benzamide
CAS Number
3544-24-9
Synonyms
  • m-Aminobenzamide
  • 3-(Aminocarbonyl) Aniline
  • 3-Carboxamidoaniline
  • NSC 36962
Molecular Formula
C7H8N2O
Formula Weight
136.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
218, 314 nm
SMILES
NC1=CC=CC(C(N)=O)=C1
InChi Code
InChI=1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChi Key
GSCPDZHWVNUUFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $38

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    $66

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    Product Description

    3-amino benzamide is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 5.4 µM in C3H/10T1/2 mouse stem cells).1 It inhibits spontaneous, as well as FGF2-induced, invasiveness of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 50 µM.2 3-amino benzamide (50 µM) induces tubulogenesis and reduces FGF2-induced expression of the gene encoding urokinase-type plasminogen activator (uPA) in HUVECs. It reduces telomere length in HeLaS3 human cervical cancer cells and non-cancerous COM3 hamster cells in a concentration-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rankin, P.W., Jacobson, E.L., Benjamin, R.C., et al. Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. The Journal of Biological Chemisty 264(8), 4312-4317 (1989).

    2. Caldini, R., Fanti, E., Magnelli, L., et al. Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2. Vasc. Cell 3(1), 12 (2011).

    3. Beneke, S., Cohausz, O., Malanga, M., et al. Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Res. 36(19), 6309-6317 (2008).