Polyphenolic antioxidant
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Active Metabolite(s)
22607Urolithin A 33757Urolithin B
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Ellagic Acid

Item No. 10569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,7,8-tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
CAS Number
476-66-4
Synonyms
  • Gallogen
  • Lagistase
  • TBBD
Molecular Formula
C14H6O8
Formula Weight
302.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.14 mg/ml
λmax
256, 365 nm
SMILES
OC1=C(O)C=C2C(C3=C4C=C(O)C(O)=C3OC2=O)=C1OC4=O
InChi Code
InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
InChi Key
AFSDNFLWKVMVRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $21

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    500 mg

    $77

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    1 g

    $116

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    Cayman Chemical
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    Product Description

    Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark, and peels. It has anti-carcinogenic, anti-mutagenic, anti-inflammatory, and organ-preserving properties, presumably related to its ability to alter cytochrome P450 activity and improve metabolism and clearance of xenobiotics, as well as alter immune function.1,2,3 Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Allen, C.T., Peden-Adams, M.M., EuDaly, J., et al. Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice. Immunopharmacol. Immunotoxicol. 25(3), 409-422 (2003).

    2. Heber, D. Multitargeted therapy of cancer by ellagitannins. Cancer Lett. 269(2), 262-268 (2008).

    3. Girish, C., and Pradhan, S.C. Drug development for liver diseases: Focus on picroliv, ellagic acid and curcumin. Fundam. Clin. Pharmacol. 22(6), 623-632 (2008).

    4. Selvi, B.R., Batta, K., Kishore, A.H., et al. Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. The Journal of Biological Chemisty 285(10), 7143-7152 (2010).

    5. Paluszczak, J., Krajka-Kuzniak, V., and Baer-Dubowska, W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol. Lett. 192(2), 119-125 (2010).

    6. Lea, M.A., Ibeh, C., Han, L., et al. Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Res. 30(2), 311-318 (2010).