Antagonizes hematopoietic stem cell differentiation
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Alternative(s)
14268StemRegenin 1 (hydrochloride)
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StemRegenin 1

Item No. 10625

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol
CAS Number
1227633-49-9
Synonyms
  • SR1
Molecular Formula
C24H23N5OS
Formula Weight
429.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 13 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 11 mg/ml
λmax
228, 273, 313 nm
SMILES
CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1
InChi Code
InChI=1S/C24H23N5OS/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28)
InChi Key
BGFHMYJZJZLMHW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    StemRegenin 1 (SR1) is a purine derivative that antagonizes aryl hydrocarbon receptor signaling with an IC50 value of 127 nM in CD34+ cells, which results in sustained expression of CD34.1 Human embryonic stem cells cultured with SR1 show a 50-fold increase in cells expressing CD34 (EC50 = 120 nM) and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice.1 This effect is quickly reversed with removal of SR1, which leads to rapid cell differentiation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boitano, A.E., Wang, J., Romeo, R., et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997), 1345-1348 (2010).