Antagonizes hematopoietic stem cell differentiation
Related Products
Alternative(s)
10625StemRegenin 1
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StemRegenin 1 (hydrochloride)

Item No. 14268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[[2-benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]-phenol, monohydrochloride
CAS Number
2319882-01-2
Synonyms
  • SR1
Molecular Formula
C24H23N5OS • HCl
Formula Weight
466.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
227, 273, 313 nm
SMILES
OC1=CC=C(C=C1)CCNC2=C3C(N(C(C)C)C=N3)=NC(C4=CSC5=C4C=CC=C5)=N2.Cl
InChi Code
InChI=1S/C24H23N5OS.ClH/c1-15(2)29-14-26-21-23(25-12-11-16-7-9-17(30)10-8-16)27-22(28-24(21)29)19-13-31-20-6-4-3-5-18(19)20;/h3-10,13-15,30H,11-12H2,1-2H3,(H,25,27,28);1H
InChi Key
HBLDXOQSBJSGSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

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    Product Description

    StemRegenin 1 (SR1) is a purine derivative that antagonizes aryl hydrocarbon receptor signaling with an IC50 value of 127 nM in CD34+ cells, which results in sustained expression of CD34.1 Human embryonic stem cells cultured with SR1 show a 50-fold increase in cells expressing CD34 (EC50 =120 nM) and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice.1 This effect is quickly reversed with removal of SR1, which leads to rapid cell differentiation. SR1 (hydrochloride) has a formulation with greater solubility in aqueous buffers than standard SR1 (Item No. 10625).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boitano, A.E., Wang, J., Romeo, R., et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997), 1345-1348 (2010).