A weak TP receptor agonist
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Labeled Version(s)
311210Prostaglandin B2-d4
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Prostaglandin B2

Item No. 11210

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-oxo-15S-hydroxy-prosta-5Z,8(12),13E-trien-1-oic acid
CAS Number
13367-85-6
Synonyms
  • PGB2
Molecular Formula
C20H30O4
Formula Weight
334.5
Purity
≥98%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: >75 mg/mlDMSO: >50 mg/mlEthanol: >100 mg/mlPBS pH 7.2: >2 mg/ml
λmax
278 nm
SMILES
O=C1C(C/C=C\CCCC(O)=O)=C(/C=C/[C@@H](O)CCCCC)CC1
InChi Code
InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1
InChi Key
PRFXRIUZNKLRHM-HKVRTXJWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Prostaglandin B2 (PGB2) is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 µg/kg).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, F., Orr, J.A., and Wu, J.Y. Prostaglandin B2-induced pulmonary hypertension is mediated by TXA2/PGH2 receptor stimulation. Am. J. Physiol. 1040, L602-L607 (1994).

    Product Citations

    Sorgi, C.A., Peti, A.P.F., Petta, T., et al. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci. Data 5, 180167 (2018).

    Grishina, Z.V., Pushkareva, M.A., Pletjushkina, O.Y., et al. Sulfatides inhibit leukotriene synthesis in human polymorphonuclear granulocytes by a mechanism involving lipid rearrangement in intracellular membranes. Int. J. Biochem. Cell Biol. 40(1), 110-124 (2008).