An inhibitor of SGLT2
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Labeled Version(s)
25223Canagliflozin-d4
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Canagliflozin

Item No. 11575

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
CAS Number
842133-18-0
Synonyms
  • JNJ-24831754
  • TA-7284
Molecular Formula
C24H25FO5S
Formula Weight
444.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH7.2) (1:7): 0.125 mg/ml
λmax
288, 291 nm
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](C2=CC=C(C)C(CC3=CC=C(C4=CC=C(F)C=C4)S3)=C2)[C@@H]1O
InChi Code
InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1
InChi Key
XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $110

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    25 mg

    $213

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    50 mg

    $392

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).1 Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.1,2 Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nomura, S., Sakamaki, S., Hongu, M., et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J. Med. Chem. 53(17), 6355-6360 (2010).

    2. Sha, S., Devineni, D., Ghosh, A., et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes. Metab. 13(7), 669-672 (2011).

    3. Reed, J.W. Impact of sodium-glucose cotransporter 2 inhibitors on blood pressure. Vasc. Health Risk Manag. 12, 393-405 (2016).