An internal standard for the quantification of canagliflozin
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Unlabeled Version(s)
11575Canagliflozin
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Canagliflozin-d4

Item No. 25223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl-2,3,5,6-d4)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
CAS Number
1997338-61-0
Molecular Formula
C24H21D4FO5S
Formula Weight
448.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](C2=CC=C(C)C(CC3=CC=C(C4=C([2H])C([2H])=C(F)C([2H])=C4[2H])S3)=C2)[C@@H]1O
InChi Code
InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1/i4D,5D,6D,7D
InChi Key
XTNGUQKDFGDXSJ-OQRSEGJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $569

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Canagliflozin-d4 is intended for use as an internal standard for the quantification of canagliflozin (Item No. 11575) by GC- or LC-MS. Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).1 Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.1,2 Formulations containing SGLT2 inhibitors, including canagliflozin, have been used to treat type 2 diabetes mellitus.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nomura, S., Sakamaki, S., Hongu, M., et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J. Med. Chem. 53(17), 6355-6360 (2010).

    2. Sha, S., Devineni, D., Ghosh, A., et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes. Metab. 13(7), 669-672 (2011).

    3. Reed, J.W. Impact of sodium-glucose cotransporter 2 inhibitors on blood pressure. Vasc. Health Risk Manag. 12, 393-405 (2016).