A hypoglycemic agent
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Labeled Version(s)
30074Glipizide-d11
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Glipizide

Item No. 11579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-2-pyrazinecarboxamide
CAS Number
29094-61-9
Synonyms
  • CP 28720
  • K 4024
  • TK 1320
Molecular Formula
C21H27N5O4S
Formula Weight
445.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
227, 275 nm
SMILES
CC1=NC=C(C(NCCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)=O)N=C1
InChi Code
InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChi Key
ZJJXGWJIGJFDTL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Glipizide is a hypoglycemic agent.1 It inhibits ATP-sensitive potassium (KATP) channels in primary mouse pancreatic β cells (IC50 = 6.4 nM). Glipizide induces insulin release from isolated rat pancreatic tissue with an EC50 value of 40 nM.2 Dietary administration of glipizide (5 mg/kg per day for 10 days) increases the number of insulin receptors on isolated and purified mouse liver plasma membranes.3 It reduces plasma glucose and triglyceride, but not total cholesterol, levels and increases plasma insulin levels in a rat model of diabetes induced by a high-fat diet and streptozotocin (STZ; Item No. 13104) when administered orally at a dose of 5 mg/kg.4 Formulations containing glipizide have been used in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zünkler, B.J., Lenzen, S., Männer, K., et al. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn-Schmiedebergs Arch. Pharmacol. 337(2), 225-230 (1998).

    2. Herchuelz, A., and Malaisse, W.J. Insulinotropic potency of glipizide in vitro. Diabetologia 309-310 (1973).

    3. Feinglos, M.N., and Lebovitz, H.E. Sulphonylureas increase the number of insulin receptors. Nature 276(5684), 184-185 (1978).

    4. Srinivasan, K., Viswanad, B., Asrat, L., et al. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol. Res. 52(4), 313-320 (2005).