DL-3,4-Dihydroxyphenyl glycol

DL-3,4-Dihydroxyphenyl glycol is an active metabolite of the endogenous neurotransmitter norepinephrine (Item No. 35580).¹ It is produced by the deamination of norepinephrine by monoamine oxidase (MAO) in the cytosol.² DL-3,4-Dihydroxyphenyl glycol scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC₅₀ = 1.55 µM).³ It reduces LPS-induced nitrite production in isolated mouse peritoneal macrophages when used at concentrations of 50 and 100 µM. DL-3,4-Dihydroxyphenyl glycol (50 and 100 µM) decreases increases in inducible nitric oxide synthase (iNOS) and COX-2 levels induced by LPS in isolated mouse macrophages. It also inhibits LPS-induced degradation of IκBα in isolated mouse macrophages.

WARNING This product is not for human or veterinary use.

1. Jonason, J., and Rutledge, C.O. The effect of protriptyline on the metabolism of dopamine and noradrenaline in rabbit brain in vitro. Acta Physiol. Scand. 73(1), 161-175 (1968).

2. Padala, N.S.P., Ajjala, D.R., Boggavarapu, R.K., et al. LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions. Bioanalysis 11(10), 971-986 (2019).

3. Aparicio-Soto, M., Sánchez-Fidalgo, S., González-Benjumea, A., et al. Naturally occurring hydroxytyrosol derivatives: Hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements. J. Agric. Food Chem. 63(3), 836-846 (2015).