An amino acid with antidiabetic activity
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4-Hydroxyisoleucine

Item No. 11812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-2,3,5-trideoxy-3-methyl-L-ribonic acid
CAS Number
55399-93-4
Synonyms
  • (4S)-4-Hydroxy-L-isoleucine
  • 4-OH-Ile
Molecular Formula
C6H13NO3
Formula Weight
147.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 5mg/mL
SMILES
C[C@H](O)[C@H](C)[C@H](N)C(O)=O
InChi Code
InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5?/m0/s1
InChi Key
OSCCDBFHNMXNME-QRHDOFTISA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $28

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    50 mg

    $42

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    100 mg

    $66

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity.1,2,3 It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.1 In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide (Item No. 11127) and streptozotocin (STZ; Item No. 13104) when administered at 25 mg/kg.2 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Broca, C., Manteghetti, M., Gross, R., et al. 4-Hydroxyisoleucine: Effects of synthetic and natural analogues on insulin secretion. Eur. J. Pharmacol. 390(3), 339-345 (2000).

    2. Broca, C., Breil, V., Cruciani-Guglielmacci, C., et al. Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat. Am. J. Physiol. Endocrinol. Metab. 287(3), E463-E471 (2004).

    3. Haeri, M.R., Limaki, H.K., White, C.J., et al. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine 19(7), 571-574 (2012).