A dietary flavonoid
Related Products
Active Metabolite(s)
34645Kaempferol 3-glucuronide
Isomer(s)
15246Fisetin
Technical Support & Resources

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Kaempferol

Item No. 11852

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
520-18-3
Synonyms
  • Nimbecetin
  • NSC 407289
  • NSC 656277
  • Pelargidenon
  • Rhamnolutein
  • Swartziol
  • Trifolitin
Molecular Formula
C15H10O6
Formula Weight
286.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
λmax
204, 267, 368 nm
SMILES
OC1=C(C2=CC=C(O)C=C2)OC3=C(C1=O)C(O)=CC(O)=C3
InChi Code
InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChi Key
IYRMWMYZSQPJKC-UHFFFAOYSA-N
Origin
Plant/Centella asiatica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $54

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    50 mg

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    100 mg

    $130

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    Product Description

    Kaempferol is a flavonoid which is abundant in a variety of plant leaves and fruits. It has diverse physiological activities through both direct and indirect effects.1,2 For example, kaempferol directly binds estrogen receptors α and β, acting as an inverse agonist or agonist.3,4 It also acts as an antioxidant, which presumably contributes to its ability to suppress advanced glycation endproduct-induced NADPH oxidase, NF-κB signaling, and hypoxia-inducible factor-related angiogenesis and VEGF expression.5,6 Kaempferol also suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.7,8,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Calderón-Montaño, J.M., Burgos-Morón, E., Pérez-Guerrero, C., et al. A review on the dietary flavonoid kaempferol. Mini Rev. Med. Chem. 11, 298-344 (2011).

    2. Aiyer, H.S., Warri, A.M., Woode, D.R., et al. Influence of berry polyphenols on receptor signaling and cell-death pathways: Implications for breast cancer prevention. J. Agric. Food Chem. 60(23), 5693-5708 (2012).

    3. Wang, J., Fang, F., Huang, Z., et al. Kaempferol is an estrogen-related receptor α and γ inverse agonist. FEBS Lett. 583(4), 643-647 (2009).

    4. Guo, A.J., Choi, R.C., Zheng, K.Y., et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin.Med. 7, 1-7 (2012).

    5. Kim, J.M., Lee, E.K., Kim, D.H., et al. Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase. Age (Dordr) 32(2), 197-208 (2010).

    6. Luo, H., Rankin, G.O., Liu, L., et al. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr. Cancer 61(4), 554-563 (2009).

    7. Kumamoto, T., Fujii, M., and Hou, D.X. Myricetin directly targets JAK1 to inhibit cell transformation. Cancer Lett. 275(1), 17-26 (2009).

    8. Labbé, D., Provençal, M., Lamy, S., et al. The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration. J. Nutr. 139(4), 646-652 (2009).

    Product Citations

    Marín, L., Gutiérrez-Del-Río, I., Villar, C.J., et al. De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity. Microb. Biotechnol. 14(5), 2009-2024 (2021).