A flavonol glycoside and an active metabolite of kaempferol with diverse biological activities
Related Products
Parent Compound(s)
11852Kaempferol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Kaempferol 3-glucuronide

Item No. 34645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl β-D-glucopyranosiduronic acid
CAS Number
22688-78-4
Synonyms
  • Kaempferol 3-O-β-glucuronide
Molecular Formula
C21H18O12
Formula Weight
462.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
268, 354 nm
SMILES
O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)C(O)=O)=C(C2=CC=C(C=C2)O)OC3=CC(O)=C4)C3=C4O
InChi Code
InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)17-18(13(25)12-10(24)5-9(23)6-11(12)31-17)32-21-16(28)14(26)15(27)19(33-21)20(29)30/h1-6,14-16,19,21-24,26-28H,(H,29,30)/t14-,15-,16+,19-,21+/m0/s1
InChi Key
FNTJVYCFNVUBOL-ZUGPOPFOSA-N
Origin
Plant/Styphnolobium japonicum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $61

    Add

    1 mg

    $116

    Add

    5 mg

    $363

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Kaempferol 3-glucuronide is a flavonol glycoside that has been found in Fragaria and an active metabolite of kaempferol (Item No. 11852) that has diverse biological activities.1,2,3,4 It is formed from kaempferol primarily in the small intestine.2 Kaempferol 3-glucuronide (0.1, 1, and 10 µM) induces Akt activity in mouse liver homogenates and increases glucose consumption in HepG2 cells.3 It inhibits the production of reactive oxygen species (ROS) induced by fMLP (Item No. 21495) in isolated human neutrophils when used at concentrations of 1 and 10 µM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ryan, J.J. Flavonol glycosides of the cultivated strawberry. J. Food Sci. 36(6), 867-870 (1971).

    2. Zheng, L., Zhu, L., Zhao, M., et al. In vivo exposure of kaempferol is driven by phase II metabolic enzymes and efflux transporters. AAPS J. 18(5), 1289-1299 (2016).

    3. Fang, G., Cheng, C., Zhang, M., et al. The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism. J. Funct. Foods 82, 104501 (2021).

    4. Granica, S., Czerwińska, M.E., Żyżyńska-Granica, B., et al. Antioxidant and anti-inflammatory flavonol glucuronides from Polygonum aviculare L. Fioterapia 91, 180-188 (2013).