A PPARγ partial agonist
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GQ-16

Item No. 11908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5Z-[(5-bromo-2-methoxyphenyl)methylene]-3-[(4-methylphenyl)methyl]-2,4-thiazolidinedione
CAS Number
870554-67-9
Molecular Formula
C19H16BrNO3S
Formula Weight
418.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.33 mg/ml
λmax
213, 308, 359 nm
SMILES
BrC1=CC(/C=C2C(N(CC3=CC=C(C)C=C3)C(S/2)=O)=O)=C(OC)C=C1
InChi Code
InChI=1S/C19H16BrNO3S/c1-12-3-5-13(6-4-12)11-21-18(22)17(25-19(21)23)10-14-9-15(20)7-8-16(14)24-2/h3-10H,11H2,1-2H3/b17-10-
InChi Key
AMLZLORVKZAHOH-YVLHZVERSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    50 mg

    $268

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    100 mg

    $469

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    GQ-16 is a partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone (Item No. 71740).1 Like rosiglitazone, GQ-16 reverses high fat diet-mediated impairments in insulin signaling.1 However, GQ-16 does not induce weight gain, hyperphagia, or edema. GQ-16 does not activate PPARα, PPARβ/δ, or RXRα.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amato, A.A., Rajagopalan, S., Lin, J.Z., et al. GQ-16, a novel PPARγ ligand, promotes insulin sensitization without weight gain. The Journal of Biological Chemisty 287(33), 28169-28179 (2012).