A selective CB1 receptor antagonist
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CP 945,598 (hydrochloride)

Item No. 11955

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[8-(2-chlorophenyl)-9-4-chlorophenyl)-9H-purine-6-yl]-4-ethylamino)-4-piperidinecarboxamide, monohydrochloride
CAS Number
686347-12-6
Synonyms
  • Otenabant
Molecular Formula
C25H25Cl2N7O • HCl
Formula Weight
546.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.30 mg/ml
λmax
281 nm
SMILES
ClC(C=CC=C1)=C1C2=NC3=C(N4CCC(NCC)(C(N)=O)CC4)N=CN=C3N2C5=CC=C(Cl)C=C5.Cl
InChi Code
InChI=1S/C25H25Cl2N7O.ClH/c1-2-31-25(24(28)35)11-13-33(14-12-25)22-20-23(30-15-29-22)34(17-9-7-16(26)8-10-17)21(32-20)18-5-3-4-6-19(18)27;/h3-10,15,31H,2,11-14H2,1H3,(H2,28,35);1H
InChi Key
KPYUQCJBZGQHPL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    CP 945,598 (hydrochloride) is a selective antagonist of the cannabinoid receptor CB1 with a Ki value of 0.7 nM and demonstrates relatively low affinity for CB2 receptors (Ki = 7.6 µM).1,2 It is reported to reverse cannabinoid agonist-mediated responses (i.e., hypo-locomotion, hypothermia, analgesia, and catalepsy), to reduce food intake, and to increase energy expenditure as well as fat oxidation in rats.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffith, D.A., Hadcock, J.R., Black, S.C., et al. Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J. Med. Chem. 52(2), 234-237 (2009).

    2. Hadcock, J.R., Griffith, D.A., Iredale, P.A., et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem. Biophys. Res. Commun. 394(2), 366-371 (2010).