An internal standard for the quantification of atropine
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Unlabeled Version(s)
12008Atropine
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Atropine-d5

Item No. 30734

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(hydroxymethyl)-benzene-2,3,4,5,6-d5-acetic acid, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS Number
2124269-77-6
Synonyms
  • DL-Hyoscyamine-d5
  • Tropine tropate-d5
Molecular Formula
C17H18D5NO3
Formula Weight
294.4
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleEthanol: Slightly solubleMethanol: Slightly soluble
SMILES
O=C(C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])CO)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2
InChi Code
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?/i2D,3D,4D,5D,6D
InChi Key
RKUNBYITZUJHSG-LGOMFLOESA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    2.5 mg

    $329

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    Product Description

    Atropine-d5 is intended for use as an internal standard for the quantification of atropine (Item No. 12008) by GC- or LC-MS. Atropine is a tropane alkaloid that has been found in A. belladonna and acts as a non-selective, competitive antagonist of muscarinic acetylcholine receptors (KBs = 0.16-1.26 nM for the M1-M5 receptors).1,2 Atropine increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine receptor sites, and decreases bronchial secretions.3 Formulations containing atropine have been used to induce mydriasis for ophthalmological exams and in the treatment of cardiac arrest and organophosphate pesticide or muscarinic mushroom poisoning.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sharp, J.M., and Doran, P.M. Characteristics of growth and tropane alkaloid synthesis in Atropa belladonna roots transformed by Agrobacterium rhizogenes. J. Biotechnol. 16(3-4), 171-185 (1990).

    2. Caulfield, M.P., and Birdsall, N.J.M. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol. Rev. 50(2), 279-290 (1998).

    3. Broadley, K.J., and Kelly, D.R. Muscarinic receptor agonists and antagonists. Molecules 6(3), 142-193 (2001).