A HAT inhibitor
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CPTH2 (hydrochloride)

Item No. 12086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone-cyclopentanone, monohydrochloride
CAS Number
2108899-91-6
Molecular Formula
C14H14ClN3S • HCl
Formula Weight
328.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 16 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.30 mg/mlEthanol: 5 mg/ml
λmax
250, 280 nm
SMILES
ClC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC\3)=N2.Cl
InChi Code
InChI=1S/C14H14ClN3S.ClH/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12;/h5-9H,1-4H2,(H,16,18);1H
InChi Key
ODVWZAKKCNHATB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $107

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    10 mg

    $141

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    Product Description

    Gcn5 is a chromatin modifying factor whose HAT activity is required to acetylate histone H3 lysine 9 (K9) and K14, which facilitates transcription elongation by relaxing nucleosomes. CPTH2 inhibits the HAT activity of Gcn5 both in vitro and in vivo, reducing histone H3K14 acetylation at a concentration of 0.8 mM.1 It is a useful tool to study the impact of Gcn5-dependent acetylation in various biological systems and recently has been used to control the replication of human adenovirus.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chimenti, F., Bizzarri, B., Maccioni, E., et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: Cyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl)hydrazone. J. Med. Chem. 52(2), 530-536 (2009).

    2. Ablack, J.N.G., Cohen, M., Thillainadesan, G., et al. Cellular GCN5 is a novel regulator of human adenovirus E1A-conserved region 3 transactivation. J. Virol. 86(15), 8198-8209 (2012).

    Product Citations

    Kanada, F., Takamura, Y., Miyake, S., et al. Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract. Sci. Rep. 9(1), 20085 (2019).