A HAT inhibitor
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Butyrolactone 3

Item No. 12095

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-tetrahydro-4-methylene-5-oxo-2R-propyl-3S-furancarboxylic acid
CAS Number
778649-18-6
Molecular Formula
C9H12O4
Formula Weight
184.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 13 mg/mlDMSO: 14 mg/mlEthanol: 14 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
O=C1C([C@@H](C(O)=O)[C@H](CCC)O1)=C
InChi Code
InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1
InChi Key
SRQUTZJZABSZRQ-NKWVEPMBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $60

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    5 mg

    $171

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    Product Description

    Butyrolactone 3 specifically inhibits the histone acetyltransferase Gcn5 with an IC50 value of 100 μM and has an affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3.1 Butyrolactone 3 can inhibit pre-RNA splicing with an IC50 value of 0.5 mM and as such has been used to investigate Gcn5/PCAF-like HAT functions during assembly of spliceosome before pre-mRNA translation.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Biel, M., Kretsovali, A., Karatzali, E., et al. Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5. Angew. Chem. Int. Ed. Engl. 43(30), 3974-3976 (2004).

    2. Kuhn, A.N., Van Santen, M.A., Schwienhorst, A., et al. Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA 15(1), 153-175 (2009).