A mycotoxin
Related Products
Isomer(s)
20434Fumonisin B3
Labeled Version(s)
31273Fumonisin B2-13C34
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Product Type

Environmental Toxicology
Toxins
Mycotoxins

Research Area

Cancer

Fumonisin B2

Item No. 13227

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-[(1S,2R)-1-[(2S,9R,11S,12S)-12-amino-9,11-dihydroxy-2-methyltridecyl]-2-[(1R)-1-methylpentyl]-1,2-ethanediyl]ester-1,2,3-propanetricarboxylic acid
CAS Number
116355-84-1
Synonyms
  • FB2
Molecular Formula
C34H59NO14
Formula Weight
705.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 10 mg/mlMethanol: 10 mg/mlPBS (pH 7.2): 15 mg/ml
SMILES
C[C@H](N)[C@@H](O)C[C@H](O)CCCCCC[C@H](C)C[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](OC(C[C@H](C(O)=O)CC(O)=O)=O)[C@H](C)CCCC
InChi Code
InChI=1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)/t20-,21+,22-,23+,24+,25+,26-,27-,32+/m0/s1
InChi Key
UXDPXZQHTDAXOZ-STOIETHLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme.1 It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml).2 FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 1,000 mg/kg for 21 days.3 FB2 has been detected in corn and corn-based foods and livestock feeds.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 54(7), 1806-1811 (1988).

    2. Shier, W.T., Abbas, H.K., and Mirocha, C.J. Toxicity of the mycotoxins fumonisins B1 and B2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cells. Mycopathologia 116(2), 97-104 (1991).

    3. Gelderblom, W.C.A., Cawood, M.E., Snyman, S.D., et al. Structure-activity relationships of fumonisins in short-term carcinogenesis and cytotoxicity assays. Food Chem. Toxicol. 31(6), 407-414 (1993).

    4. Bullerman, L.B. Occurrence of Fusarium and fumonisins on food grains and in foods. Fumonisins in food 27-38 (1996).