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CB-86

Item No. 13289

Technical Information
Formal Name
N-cyclopropyl-8-[3-(1,1-dimethylheptyl)-5-hydroxyphenoxy]-octanamide
CAS Number
1150586-64-3
Molecular Formula
C26H43NO3
Formula Weight
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
206, 275 nm
SMILES
CC(C1=CC(O)=CC(OCCCCCCCC(NC2CC2)=O)=C1)(C)CCCCCC
InChi Code
InChI=1S/C26H43NO3/c1-4-5-6-11-16-26(2,3)21-18-23(28)20-24(19-21)30-17-12-9-7-8-10-13-25(29)27-22-14-15-22/h18-20,22,28H,4-17H2,1-3H3,(H,27,29)
InChi Key
PVAOGZXUOOHSMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the central cannabinoid (CB1) receptor and a neutral antagonist for the peripheral cannabinoid (CB2) receptor with Ki values of 5.6 and 7.9 nM, respectively.1 Its demonstrated potency is similar to that of WIN 55,212-2 (Ki = 21 and 2.1 nM for CB1 and CB2, respectively).1 CB-86 (1 mg/kg) exhibits antinociceptive effects in mice treated with formalin.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brizzi, A., Brizzi, V., Cascio, M.G., et alNew resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo. J. Med. Chem. 52, 2506-2514 (2009).