A PKC inhibitor
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Bisindolylmaleimide IV

Item No. 13299

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione
CAS Number
119139-23-0
Synonyms
  • Arcyriarubin A
  • BIM IV
Molecular Formula
C20H13N3O2
Formula Weight
327.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
276, 373, 461 nm
SMILES
O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
InChi Code
InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
InChi Key
DQYBRTASHMYDJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM.1,2,3,4 BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Item No. 81590). However, BIM IV also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davis, P.D., Hill, C.H., Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. J. Med. Chem. 35(1), 177-184 (1992).

    2. Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of Biological Chemisty 266(24), 15771-15781 (1991).

    3. Fabre, S., and Prudhomme, M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg. Med. Chem. 1(3), 193-196 (1993).

    4. Lazareno, S., Popham, A., and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. Eur. J. Pharmacol. 360(2-3), 281-284 (1998).