An anticoagulant
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(+)-Warfarin

Item No. 13526

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one
CAS Number
5543-58-8
Synonyms
  • (R)-Warfarin
Molecular Formula
C19H16O4
Formula Weight
308.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 5 mg/ml
λmax
207, 272, 283, 306 nm
SMILES
O=C1OC2=CC=CC=C2C(O)=C1[C@](C3=CC=CC=C3)([H])CC(C)=O
InChi Code
InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m1/s1
InChi Key
PJVWKTKQMONHTI-OAHLLOKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $85

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    5 mg

    $233

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    10 mg

    $422

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    25 mg

    $948

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    Product Description

    (+)-Warfarin is a component of (±)-warfarin (Item No. 13566). It is an anticoagulant that interferes with interconversion of vitamin K and vitamin K epoxide and the role of vitamin K in carboxylation of several clotting cascade proteins, inhibiting the initiation of clotting.1 In vivo, (+)-warfarin slows formation of the prothrombin complex but exhibits 6.6-fold less potent anticoagulant activity than (–)-warfarin (Item No. 13531) in rats.2 Formulations containing warfarin have been used to treat and prevent blood clots in atrial fibrillation, heart valve replacement, venous thrombosis, and pulmonary embolism.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hirsh, J., Fuster, V., Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J. Am. Coll. Cardiol. 41(9), 1633-1652 (2003).

    2. Breckenridge, A., and Orme, M.L. The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats. Life Sci. II 11(7), 337-345 (1972).