A metabolite of (R)-warfarin
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10-hydroxy Warfarin

Item No. 33929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
CAS Number
83219-99-2
Molecular Formula
C19H16O5
Formula Weight
324.3
Purity
≥95% (mixture of diastereomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
OC(C1=CC=CC=C1O2)=C(C(C3=CC=CC=C3)C(O)C(C)=O)C2=O
InChi Code
InChI=1S/C19H16O5/c1-11(20)17(21)15(12-7-3-2-4-8-12)16-18(22)13-9-5-6-10-14(13)24-19(16)23/h2-10,15,17,21-22H,1H3
InChi Key
BPZSPAZBZFZZBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $81

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    1 mg

    $152

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    Product Description

    10-hydroxy Warfarin is a metabolite of (R)-warfarin (Item No. 13526).1 It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50 = 1.6 µM), the enzyme that converts (S)-warfarin (Item No. 13531) to its 6-hydroxy warfarin (Item No. 9000632) and 7-hydroxy warfarin (Item No. 9000672) metabolites.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaminsky, L.S., and Zhang, Z.-Y. Human P450 metabolism of warfarin. Pharmacol. Ther. 73(1), 67-74 (1997).

    2. Jones, D.R., Kim, S.-Y., Guderyon, M., et al. Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem. Res. Toxicol. 23(5), 939-945 (2010).