A phase I metabolite of (-)-warfarin
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7-hydroxy Warfarin

Item No. 9000672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,7-dihydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one
CAS Number
17834-03-6
Molecular Formula
C19H16O5
Formula Weight
324.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
O=C1OC2=CC(O)=CC=C2C(O)=C1C(C3=CC=CC=C3)CC(C)=O
InChi Code
InChI=1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3
InChi Key
SKFYEJMLNMTTJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $85

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    1 mg

    $161

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    5 mg

    $674

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    10 mg

    $1,095

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    Product Description

    7-hydroxy Warfarin is a metabolite of (-)-warfarin (Item No. 13531), which is a more potent vitamin K antagonist than (+)-warfarin (Item No. 13526).1,2 Both isomers of warfarin are metabolized by the cytochrome P450 isoform 2C9 (CYP2C9). Stereoselective metabolism also occurs, and CYP2C9 is the primary enzyme responsible for metabolism of (-)-warfarin to 7-hydroxy warfarin.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaminsky, L.S., and Zhang, Z.-Y. Human P450 metabolism of warfarin. Pharmacol. Ther. 73(1), 67-74 (1997).

    2. Hirsh, J., Fuster, V., Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J. Am. Coll. Cardiol. 41(9), 1633-1652 (2003).