A glycoside with diverse biological activities
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Salidroside

Item No. 13628

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside
CAS Number
10338-51-9
Synonyms
  • Rhodioloside
Molecular Formula
C14H20O7
Formula Weight
300.3
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC1=CC=C(C=C1)CCO[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2
InChi Code
InChI=1S/C14H20O7/c15-7-10-11(17)12(18)13(19)14(21-10)20-6-5-8-1-3-9(16)4-2-8/h1-4,10-19H,5-7H2/t10-,11-,12+,13-,14-/m1/s1
InChi Key
ILRCGYURZSFMEG-RKQHYHRCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $83

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    1 mg

    $132

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    5 mg

    $537

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    10 mg

    $908

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    Product Description

    Salidroside is a glycoside that has been found in R. rosea and has diverse biological activities, including antioxidant, anti-apoptotic, neuroprotective, and anti-inflammatory properties.1,2,3,4,5 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with EC50 values of 81.54 and 30.94 µg/ml, respectively, in cell-free assays.2 Salidroside (50 and 100 µM) inhibits apoptosis and production of reactive oxygen species (ROS) induced by amyloid-β (25-35) (Aβ (23-35)) in SH-SY5Y neuroblastoma cells.3 It decreases infarct volume by 17.9% in a rat model of focal cerebral ischemia-reperfusion injury induced by transient middle cerebral artery occlusion (MCAO) when administered at a dose of 12 mg/kg.4 Salidroside (20, 50, and 100 mg/kg, p.o.) increases survival and reduces plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), TNF-α, and malondialdehyde (MDA) levels in a mouse model of liver injury induced by acetaminophen (Item No. 10024).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, C., Tang, J., Wang, H., et al. Preparative purification of salidroside from Rhodiola rosea by two-step adsorption chromatography on resins. J. Sep. Sci. 32(2), 185-191 (2009).

    2. Wang, H., Gan, D., Zhang, X., et al. Antioxidant capacity of the extracts from pulp of Osmanthus fragrans and its components. LWT Food Sci. Technol. 43(2), 319-325 (2010).

    3. Zhang, L., Yu, H., Zhao, X., et al. Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem. Int. 57(5), 547-555 (2010).

    4. Shi, T.-y., Feng, S.-f., Xing, J.-h., et al. Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro. Neurotox. Res. 21(4), 358-367 (2012).

    5. Wu, Y.-L., Piao, D.-M., Han, X.-H., et al. Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol. PHarm. Bull. 31(8), 1523-1529 (2008).