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Dextromethorphan (hydrobromide hydrate)

Item No. 13950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(9α,13α,14α)-3-methoxy-17-methyl-morphinan, hydrobromide monohydrate
CAS Number
6700-34-1
Molecular Formula
C18H25NO • HBr [H2O]
Formula Weight
370.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
227, 280 nm
SMILES
CN1[C@@H]2[C@@]3([H])CCCC[C@@]3(CC1)C4=CC(OC)=CC=C4C2
InChi Code
InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
InChi Key
MKXZASYAUGDDCJ-NJAFHUGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dextromethorphan (hydrobromide hydrate) (Item No. 13950) is an analytical reference standard categorized as an antitussive.1 Dextromethorphan has analgesic and anticonvulsant activities in rodents.2,3 It has been found as an adulterant in 3,4-MDMA and has potential for abuse.4,5 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bolser, D.C., Aziz, S.M., DeGennaro, F.C., et al. Antitussive effects of GABAB agonists in the cat and guinea-pig. Br. J. Pharmacol. 110(1), 491-495 (1993).

    2. Chen, Y.W., Chu, K.S., Lin, C.N., et al. Dextromethorphan or dextrorphan have a local anesthetic effect on infiltrative cutaneous analgesia in rats. Anesth. Analg. 104(5), 1251-1255 (2007).

    3. Jamali, H., and Heydari, A. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci. Lett. 729, 134988 (2020).

    4. Cole, C., Jones, L., McVeigh, J., et al. CUT: A guide to adulterants, bulking agents and other contaminants found in illicit drugs. (2010).

    5. Chomchai, C., and Manaboriboon, B. Stimulant methamphetamine and dextromethorphan use among Thai adolescents: Implications for health of women and children. J. Med. Toxicol. 8(3), 291-294 (2012).