A polypharmacological cancer therapeutic
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AD57 (hydrochloride)

Item No. 13975

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea, monohydrochloride
CAS Number
2320261-72-9
Molecular Formula
C22H20F3N7O • HCl
Formula Weight
491.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
203, 271 nm
SMILES
CC(C)N1C2=NC=NC(N)=C2C(C3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4)=O)C=C3)=N1.Cl
InChi Code
InChI=1S/C22H20F3N7O.ClH/c1-12(2)32-20-17(19(26)27-11-28-20)18(31-32)13-6-8-15(9-7-13)29-21(33)30-16-5-3-4-14(10-16)22(23,24)25;/h3-12H,1-2H3,(H2,26,27,28)(H2,29,30,33);1H
InChi Key
DUBKXOIZTZQJIW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

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    Product Description

    AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.1 In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 486(7401), 80-84 (2012).