A PTEN inhibitor
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Contained In
502886Stem Cell Expansion Kit (SCB)
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bpV(pic) (potassium hydrate)

Item No. 14434

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(PB-7-23-111'1'4)-oxodiperoxy(2-pyridinecarboxylato-κN1,κO2)-vanadate(2-), dipotassium, dihydrate
CAS Number
148556-27-8
Synonyms
  • Bisperoxovanadium(pic)
Molecular Formula
C6H4NO7V • 2K [2H2O]
Formula Weight
367.3
Purity
≥96%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=[V+3]12([O-]3)([O-][O-]1)([O-][O-]2)[N]4=CC=CC=C4C3=O.[K+].[K+].O.O
InChi Code
InChI=1S/C6H5NO2.2K.2O2.2H2O.O.V/c8-6(9)5-3-1-2-4-7-5;;;2*1-2;;;;/h1-4H,(H,8,9);;;;;2*1H2;;/q;2*+1;2*-2;;;;+3/p-1
InChi Key
GYVUDTPPESAZQJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $86

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    25 mg

    $363

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    Cayman Chemical
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    Product Description

    bpV(pic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 31 nM).1 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 12.7 μM), and PTP-1βB (IC50 = 61 μM).1 bpV(pic) is also known to be an insulin mimetic capable of activating the insulin receptor kinase of cultured hepatoma cells, stimulating lipogenesis in adipocytes, and inhibiting the dephosphorylation of autophosphorylated insulin receptors and epidermal growth factor receptors of rat liver endosomes.2 This product is also available as part of Cayman's Stem Cell Expansion Reagent Kit (SCB) (Item No. 502886).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmid, A.C., Byrne, R.D., Vilar, R., et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 566(1-3), 35-38 (2004).

    2. Posner, B.I., Faure, R., Burgess, J.W., et al. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. The Journal of Biological Chemisty 269(6), 4596-4604 (1994).

    Product Citations

    Kumar, R., Bhat, T.A., Walsh, E.M., et al. Cytochrome c deficiency confers apoptosome and mitochondrial dysfunction in African-American men with prostate cancer. Cancer Res. 79(7), 1353-1368 (2019).