A p300 and CBP inhibitor
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Alternative(s)
36811I-CBP112
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I-CBP112 (hydrochloride)

Item No. 14468

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)Epigenetic Chemical Probe Guide (PDF)
Technical Information
Formal Name
1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone, monohydrochloride
CAS Number
2147701-33-3
Molecular Formula
C27H36N2O5 • HCl
Formula Weight
505.1
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 16 mg/mlEthanol: 16 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
213, 269, 291 nm
SMILES
COC1=C(OC)C=C(C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2)C=C1.Cl
InChi Code
InChI=1S/C27H36N2O5.ClH/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19;/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3;1H/t19-;/m0./s1
InChi Key
NZYYXGVOYOZTHZ-FYZYNONXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    I-CBP112 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases.1 It binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively) and is selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM. I-CBP112 displaces acetylated histones from CBP in a cell-free assay (IC50 = 170 nM). It reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 µM. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Picaud, S., Fedorov, O., Thanasopoulou, A., et al. Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy. Cancer Res. 75(23), 5106-5119 (2015).