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SGC-CBP30

Item № 14469
CAS № 1613695-14-9
Purity ≥98%
product image
                (CAS 1613695-14-9)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     5 mg $89.00 0.00
     10 mg $169.00 0.00
     50 mg $668.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and 38 nM, respectively).1 Developed by the Structural Genomics Consortium (SGC), this compound displays over 40-fold selectivity for CREBBP over BRD4(1) and is functional in cells.

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Technical Information
Formal Name
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole
CAS Number
1613695-14-9
Molecular Formula
C28H33ClN4O3
Formula Weight
509.0
Purity
≥98%
Formulation
A crystalline solid
λmax
221, 287 nm
SMILES
COC(C=C1)=C(Cl)C=C1CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2C[C@H](C)N5CCOCC5
InChI Code
InChI=1S/C28H33ClN4O3/c1-18(32-11-13-35-14-12-32)17-33-25-8-7-22(28-19(2)31-36-20(28)3)16-24(25)30-27(33)10-6-21-5-9-26(34-4)23(29)15-21/h5,7-9,15-16,18H,6,10-14,17H2,1-4H3/t18-/m0/s1
InChI Key
GEPYBHCJBORHCE-SFHVURJKSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

Download SGC Epigenetic Chemical Probe Guide

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Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data pack, and GC-MS data.

References & Product Citations
Product Description References

1. Gallenkamp, D., Gelato, K.A., Haendler, B., et al. Bromodomains and their pharmacological inhibitors ChemMedChem 9(3), 438-464 (2014).

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