An inhibitor of BD1 in BRD4
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OXF BD 02

Item No. 14811

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3,5-dimethyl-4-isoxazolyl)-5-hydroxy-α-phenyl-benzenemethanol
CAS Number
1429129-68-9
Synonyms
  • BRD4 Inhibitor Compound 8
Molecular Formula
C18H17NO3
Formula Weight
295.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C1=CC(O)=CC(C2=C(C)ON=C2C)=C1)C3=CC=CC=C3
InChi Code
InChI=1S/C18H17NO3/c1-11-17(12(2)22-19-11)14-8-15(10-16(20)9-14)18(21)13-6-4-3-5-7-13/h3-10,18,20-21H,1-2H3
InChi Key
FEQUIPXIENTMJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $248

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    10 mg

    $396

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    25 mg

    $743

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    50 mg

    $990

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    Cayman Chemical
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    Product Description

    OXF BD 02 is an inhibitor of bromodomain 1 (BD1) in bromodomain-containing protein 4 (BRD4; IC50 = 382 nM).1 It is selective for BRD4 BD1 over a panel of 60 bromodomain-containing proteins but does inhibit CREB-binding protein (CBP) at 25 µM. OXF BD 02 is cytotoxic to MV4-11 acute myeloid leukemia (AML) cells (IC50 = 0.794 nM) but not A549 or H1975 lung cancer cells (IC50s = >10 µM for both) or U2OS osteosarcoma or HeLa cervical cancer cells (IC50s = >100 µM for both). OXF BD 02 also binds to recombinant S. mansoni BRD3 (SmBRD3) that contains BD1 and BD2 (Kd = 683 nM) but not recombinant BD2 of SmBRD3.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hewings, D.S., Fedorov, O., Filippakopoulos, P., et al. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J. Med. Chem. 56(8), 3217-3227 (2013).

    2. Schiedel, M., McArdle, D.J.B., Padalino, G., et al. Small molecule ligands of the BET-like bromodomain, SmBRD3, affect Schistosoma mansoni survival, oviposition, and development. J. Med. Chem. 66(23), 15801-15822 (2023).