A VEGF receptor tyrosine kinase inhibitor
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KRN 633

Item No. 14871

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-urea
CAS Number
286370-15-8
Molecular Formula
C20H21ClN4O4
Formula Weight
416.9
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 0.3 mg/ml
λmax
210, 242, 320 nm
SMILES
COC(C(OC)=C1)=CC2=C1C(OC3=CC(Cl)=C(NC(NCCC)=O)C=C3)=NC=N2
InChi Code
InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChi Key
VPBYZLCHOKSGRX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively).1 At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases.1 KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fedorov, O., Marsden, B., Pogacic, V., et al. A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc. Natl. Acad. Sci. USA 104(51), 20523-20528 (2007).

    2. Nakamura, K., Yamamoto, A., Kamishohara, M., et al. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Mol. Cancer Ther. 3(12), 1639-1649 (2004).