An antagonist of GPR55
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ML-191

Item No. 15182

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-phenyl-3-(1-(1-(p-tolyl)cyclopropane-1-carbonyl)piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one
CAS Number
931695-79-3
Synonyms
  • CCG-152883
  • CID-23612552
Molecular Formula
C24H25N3O3
Formula Weight
403.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
269 nm
SMILES
CC1=CC=C(C2(CC2)C(N3CCC(N4N=C(C5=CC=CC=C5)OC4=O)CC3)=O)C=C1
InChi Code
InChI=1S/C24H25N3O3/c1-17-7-9-19(10-8-17)24(13-14-24)22(28)26-15-11-20(12-16-26)27-23(29)30-21(25-27)18-5-3-2-4-6-18/h2-10,20H,11-16H2,1H3
InChi Key
WWJKJCDOYFKZBJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $412

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    Product Description

    ML-191 is an antagonist of GPR55.1 It inhibits GPR55 signaling induced by lysophosphatidylinositol (LPI; EC50 = 1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50 = 328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heynen-Genel, S., Dahl, R., Shi, S., et al. Selective GPR55 antagonists: Screening for selective ligands for GPR55. Probe Reports from the NIH Molecular Libraries Program (2011).