A triterpene saponin with diverse biological activities
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Active Metabolite(s)
29926Ginsenoside CK
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Ginsenoside Rb1

Item No. 15319

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
41753-43-9
Synonyms
  • Gypenoside III
  • NSC 310103
Molecular Formula
C54H92O23
Formula Weight
1109.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]5(C)CC[C@]6([H])[C@@](CC[C@H](O[C@]7([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C6(C)C)(C)[C@@]5([H])C1
InChi Code
InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1
InChi Key
GZYPWOGIYAIIPV-JBDTYSNRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Ginsenoside Rb1 is a triterpene saponin that has been found in P. ginseng and has diverse biological activities.1,2,3,4,5 It decreases apoptosis and increases in protein kinase A (PKA), PKC, caspase-3, and caspase-9 levels induced by isoproterenol (Item No. 15592) in H9c2 rat cardiomyocytes when used at a concentration of 100 µM.1 Ginsenoside Rb1 (1 µM) inhibits glucose-induced cytotoxicity and production of reactive oxygen species (ROS) in primary rat hippocampal neurons.2 It inhibits LPS-induced activation of IL-1 receptor-associated kinase 1 (IRAK1), IΚΚβ, NF-κB, as well as the MAP kinases ERK, JNK, and p38, in mouse peritoneal lavage fluid when used at a concentration of 100 µM.4 Ginsenoside Rb1 (10 mg/kg for 30 days) increases hippocampus nestin and glial fibrillary acidic protein (GFAP) levels, markers of neural stem cells and astrocytes respectively, in a rat model of Alzheimer’s disease induced by amyloid-β (1-40) (Aβ40).3 It decreases high-fat diet-induced increases in liver weight, hepatic triglyceride accumulation, serum fasting glucose levels, and serum LDL levels in a mouse model of obesity when administered at a dose of 200 mg/kg per day.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, X.F., Liu, X.j., Zhou, Q.M., et al. Ginsenoside rb1 reduces isoproterenol-induced cardiomyocytes apoptosis in vitro and in vivo. Evid. Based Complement. Alternat. Med. 2013, 454389 (2013).

    2. Liu, D., Zhang, H., Gu, W., et al. Neuroprotective effects of ginsenoside rb1 on high glucose-induced neurotoxicity in primary cultured rat hippocampal neurons. PLoS One 8(11), e793399 (2013).

    3. Zhao, J., Lu, S., Yu, H., et al. Baicalin and ginsenoside Rb1 promote the proliferation and differentiation of neural stem cells in Alzheimer’s disease model rats. Brain Res. 1678, 187-194 (2018).

    4. Joh, E.-H., Lee, I.-A., Jung, I.-H., et al. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation—the key step of inflammation. Biochem. Pharmacol. 82(3), 278-286 (2011).

    5. Yang, X., Dong, B., An, L., et al. Ginsenoside rb1 ameliorates glycemic disorder in mice with high fat diet-induced obesity via regulating gut microbiota and amino acid metabolism. Front. Pharmacol. 12, 756491 (2021).