A natural steroid glycoside with diverse effects
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Active Metabolite(s)
2907320(S)-Protopanaxatriol
Isomer(s)
23435Ginsenoside F2
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Ginsenoside Rg2

Item No. 15331

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6α)-3β,12β,20-trihydroxydammar-24-en-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
CAS Number
52286-74-5
Synonyms
  • Chikusetsusaponin I
  • Panaxoside Rg2
  • Prosapogenin C2
Molecular Formula
C42H72O13
Formula Weight
785.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O)(C)[C@]3(C)C[C@H](O[C@@]4([H])[C@H](O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@]6([H])[C@@](CC[C@H](O)C6(C)C)(C)[C@@]3([H])C1
InChi Code
InChI=1S/C42H72O13/c1-20(2)11-10-14-42(9,51)22-12-16-40(7)28(22)23(44)17-26-39(6)15-13-27(45)38(4,5)35(39)24(18-41(26,40)8)53-37-34(32(49)30(47)25(19-43)54-37)55-36-33(50)31(48)29(46)21(3)52-36/h11,21-37,43-51H,10,12-19H2,1-9H3/t21-,22-,23+,24-,25+,2
InChi Key
AGBCLJAHARWNLA-DQUQINEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $41

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    1 mg

    $69

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    5 mg

    $211

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    10 mg

    $290

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ginsenoside Rg2 is a protopanaxatriol that is more abundant in some Panax species (e.g., white and red P. ginseng) than others.1 This ginsenoside and its metabolites have diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-diabetic actions.2,3,4 It also protects against DNA damage and apoptosis induced by ultraviolet light.5 Notably, this ginsenoside is increased by the metabolism of other bioactive ginsenosides during the steaming or heating of plant materials, particularly in P. quinquefolium.1,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, C.F., Chiou, W.F., and Zhang, J.T. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol. Sin. 29(9), 1103-1108 (2008).

    2. Zhang, G., Liu, A., Zhou, Y., et al. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J. Ethnopharmacol. 115(3), 441-448 (2008).

    3. Cho, Y.S., Kim, C.H., Ha, T.S., et al. Ginsenoside Rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J. Physiol. Pharmacol. 17(2), 133-137 (2013).

    4. Yuan, H.D., Kim, D.Y., Quan, H.Y., et al. Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells. Chem. Biol. Interact. 195(1), 35-42 (2012).

    5. Ha, S.E., Shin, D.H., Kim, H.D., et al. Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells. Naunyn Schmiedebergs Arch. Pharmacol. 382(1), 89-101 (2010).

    6. Kim, I.W., Cha, K.M., Wee, J.J., et al. A new validated analytical method for the quality control of red ginseng products. J. Ginseng Res. 37(4), 475-482 (2013).