An active metabolite of midodrine
Related Products
Isomer(s)
15408Metanephrine
Pro-drug Form(s)
17349Midodrine (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Desglymidodrine

Item No. 35608

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(aminomethyl)-2,5-dimethoxy-benzenemethanol
CAS Number
3600-87-1
Synonyms
  • ST 1059
Molecular Formula
C10H15NO3
Formula Weight
197.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/mlEthanol: insolPBS (pH 7.2): insol
SMILES
OC(CN)C1=C(OC)C=CC(OC)=C1
InChi Code
InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3
InChi Key
VFRCNXKYZVQYLX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $37

    Add

    5 mg

    $108

    Add

    10 mg

    $181

    Add
    Product Description

    Desglymidodrine is the active metabolite of the prodrug midodrine (Item No. 17349).1 It is formed from midodrine by enzymatic hydrolysis.2 Desglymidodrine is an agonist of α1-adrenergic receptors (α1-ARs).1 It binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively) and increases intraurethral pressure (IUP) and mean arterial pressure (MAP) by 5 and 20 mm Hg, respectively, in anesthetized dogs at doses of 205 and 250 nmol/kg, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Altenbach, R.J., Khilevich, A., Kolasa, T., et al. Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing α1A-adrenoceptor agonist. J. Med. Chem. 47(12), 3220-3235 (2004).

    2. McClellan, K.J., Wiseman, L.R., and Wilde, M.I. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging 12(1), 76-86 (1998).