An anticonvulsant
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Lamotrigine

Item No. 15428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
CAS Number
84057-84-1
Synonyms
  • BW 430C
  • LTG
Molecular Formula
C9H7Cl2N5
Formula Weight
256.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
SMILES
ClC1=C(Cl)C(C2=NN=C(N)N=C2N)=CC=C1
InChi Code
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
InChi Key
PYZRQGJRPPTADH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $63

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    25 mg

    $90

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    50 mg

    $168

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    100 mg

    $291

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    Product Description

    Lamotrigine is an anticonvulsant.1 It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA (Item No. 24114) and P-type calcium channel blocker ω-agatoxin IVA (Item No. 21605).1,2 Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).3 It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).1 Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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