A gastroprotective agent
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Irsogladine (maleate)

Item No. 30223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine, 2Z-butenedioate
CAS Number
84504-69-8
Molecular Formula
C9H7Cl2N5 • C4H4O4
Formula Weight
372.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
ClC1=CC=C(Cl)C(C2=NC(N)=NC(N)=N2)=C1.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
PJLVTVAIERNDEQ-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Irsogladine is a gastroprotective agent.1,2,3 It increases transfer of Lucifer yellow CH (Item No. 25573) between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC).2 Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME (Item No. 80210).1 It also inhibits superoxide anion production induced by fMLP (Item No. 21495) and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram (Item No. 10011132).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kyoi, T., Oka, M., Noda, K., et al. Irsogladine prevents monochloramine-induced gastric mucosal lesions by improving the decrease in mucosal blood flow due to the disturbance of nitric oxide synthesis in rats. J. Pharmacol. Sci. 93(3), 314-320 (2003).

    2. Ueda, F., Ban, K., and Ishima, T. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor. J. Pharm. Exp. Ther. 274(2), 815-819 (1995).

    3. Kyoi, T., Noda, K., Oka, M., et al. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci. 76(1), 71-83 (2004).