An inhibitor of cell proliferation
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LY303511 (hydrochloride)

Item No. 15514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one, dihydrochloride
CAS Number
854127-90-5
Molecular Formula
C19H18N2O2 • 2HCl
Formula Weight
379.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
O=C1C=C(N2CCNCC2)OC3=C1C=CC=C3C4=CC=CC=C4.Cl.Cl
InChi Code
InChI=1S/C19H18N2O2.2ClH/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14;;/h1-8,13,20H,9-12H2;2*1H
InChi Key
GUISTZFSXPSDQO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $176

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    Product Description

    LY303511 is a close structural analog of LY294002 (Item No. 70920), a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.1 LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K.1 It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting casein kinase 2 activity.1 LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis.2 LY303511 is also reported to block voltage-gated potassium (Kv) channels.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kristof, A.S., Pacheco-Rodriguez, G., Schremmer, B., et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J. Pharmacol. Exp. Ther. 314(3), 1134-1143 (2005).

    2. Mellier, G., Liu, D., Bellot, G., et al. Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27. Cell Death Dis. 4, e890 (2013).

    3. Pattnaik, B.R., and Hughes, B.A. Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. Am. J. Physiol. Cell Physiol. 297(4), C1001-C1011 (2009).