An insulin receptor tyrosine kinase inhibitor
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Pro-drug Form(s)
23245HNMPA-(AM)3
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HNMPA

Item No. 15543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-(hydroxy-2-naphthalenylmethyl)-phosphonic acid
CAS Number
132541-52-7
Synonyms
  • Hydroxy-2-naphthalenylmethyl Phosphonic Acid
Molecular Formula
C11H11O4P
Formula Weight
238.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 1 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
228 nm
SMILES
OC(P(O)(O)=O)C1=CC2=CC=CC=C2C=C1
InChi Code
InChI=1S/C11H11O4P/c12-11(16(13,14)15)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11-12H,(H2,13,14,15)
InChi Key
AMJJLDJPDLKNJA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $86

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    10 mg

    $153

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    25 mg

    $336

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    Cayman Chemical
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    Product Description

    HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.1 It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities.1 HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 µM in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baltensperger, K., Lewis, R.E., Woon, C.W., et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc. Natl. Acad. Sci. USA 89(17), 7885-7889 (1992).