A cell-permeable prodrug form of HNMPA
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Active Metabolite(s)
15543HNMPA
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HNMPA-(AM)3

Item No. 23245

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[[(acetyloxy)methoxy]-2-naphthalenylmethyl]-phosphonic acid, bis[(acetyloxy)methyl] ester
CAS Number
120944-03-8
Molecular Formula
C20H23O10P
Formula Weight
454.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 1 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
229 nm
SMILES
CC(OCOC(P(OCOC(C)=O)(OCOC(C)=O)=O)C1=CC2=CC=CC=C2C=C1)=O
InChi Code
InChI=1S/C20H23O10P/c1-14(21)25-11-28-20(19-9-8-17-6-4-5-7-18(17)10-19)31(24,29-12-26-15(2)22)30-13-27-16(3)23/h4-10,20H,11-13H2,1-3H3
InChi Key
UQODAZKXEREJLZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $257

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    10 mg

    $486

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    HNMPA-(AM)3 is a cell-permeable prodrug form of the insulin receptor tyrosine kinase (IRTK) inhibitor HNMPA (Item No. 15543).1 HNMPA-(AM)3 inhibits IRTK autophosphorylation in CHO cells expressing the human receptor in a concentration- and time-dependent manner. It inhibits 2-deoxyglucose uptake but does not affect insulin-stimulated thymidine uptake in CHO cells at concentrations up to 100 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saperstein, R., Vicario, P.P., Strout, H.V., et al. Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells. Biochemistry 28(13), 5694-5701 (1989).