An inhibitor of Akt activation
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Akt Inhibitor IV

Item No. 15569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2-benzothiazolyl)-1-ethyl-2-[2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium, monoiodide
CAS Number
681281-88-9
Molecular Formula
C31H27N4S • I
Formula Weight
614.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
386 nm
SMILES
CC[N+]1=C(/C=C/N(C2=CC=CC=C2)C)N(C3=CC=CC=C3)C4=CC=C(C5=NC(C=CC=C6)=C6S5)C=C41.[I-]
InChi Code
InChI=1S/C31H27N4S.HI/c1-3-34-28-22-23(31-32-26-16-10-11-17-29(26)36-31)18-19-27(28)35(25-14-8-5-9-15-25)30(34)20-21-33(2)24-12-6-4-7-13-24;/h4-22H,3H2,1-2H3;1H/q+1;/p-1
InChi Key
NAYRELMNTQSBIN-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner.1 Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM).2 It also reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kau, T.R., Schoeder, F., Ramaswamy, S., et al. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 4(6), 463-476 (2003).

    2. Sun, Q., Wu, R., Cai, S., et al. Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV. J. Med. Chem. 54(5), 1126-1139 (2011).

    3. Meinig, J.M., and Peterson, B.R. Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics. ACS Chem Biol. 10(2), 570-576 (2015).