An Analytical Reference Standard
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Active Metabolite(s)
221466α-Naloxol 221486β-Naloxol
Certified Reference Material(s)
ISO60191Naloxone (hydrochloride) (CRM)
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Naloxone (hydrochloride)

Item No. 15594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • N-Allyldihydro-14-hydroxynormorphinone
  • NIH 7890
Technical Information
Formal Name
(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-morphinan-6-one, monohydrochloride
CAS Number
357-08-4
Molecular Formula
C19H21NO4 • HCl
Formula Weight
363.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 3 mg/mlEthanol: 1 mg/ml
SMILES
O[C@]12[C@]3(CCN(CC=C)[C@@H]2C4)[C@](OC5=C3C4=CC=C5O)([H])C(CC1)=O.Cl
InChi Code
InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
InChi Key
RGPDIGOSVORSAK-STHHAXOLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Naloxone (hydrochloride) (Item No. 15594) is an analytical reference standard categorized as an opioid antagonist.1 Formulations containing naloxone have been used as antidotes for opioid overdose and the prevention of overdose. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Le Bourdonnec, B., Barker, W.M., Belanger, S., et al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg. Med. Chem. Lett. 18(6), 2006-2012 (2008).

    Product Citations

    Kang, J., Xu, R., Lee, S., et al. Discovery, structural characterization, and preclinicla evaluation of monoclonal antibodies against xylazine poisoning. ACS Pharmacol. Transl. Sci. (2026).

    Khan, S., Tyson, A.S., Ranjbar, M., et al. Structural snapshots capture nucleotide release at the μ-opioid receptor. Nature (2025).

    Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression. Pharmacol. Biochem. Behav. 226, 173572 (2023).

    Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated. Biochem. Pharmacol. 195, 114805 (2022).