A selective MEK1/2 inhibitor
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SL 327

Item No. 15598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-benzeneacetonitrile
CAS Number
305350-87-2
Molecular Formula
C16H12F3N3S
Formula Weight
335.4
Purity
≥95% (mixture of cis/trans isomers)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
278 nm
SMILES
N/C(SC1=CC=C(N)C=C1)=C(C#N)\C2=CC=CC=C2C(F)(F)F
InChi Code
InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
InChi Key
JLOXTZFYJNCPIS-FYWRMAATSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $90

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    10 mg

    $153

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    25 mg

    $303

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    Product Description

    The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2.1 It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively).1 Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scherle, P.A., Ma, W.g., Lim, H., et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. The Journal of Biological Chemisty 275(47), 37086-37092 (2000).

    2. Fasano, S., and Brambilla, R. Ras-ERK signaling in behavior: Old questions and new perspectives. Front. Behav. Neurosci. 5(79), (2011).