A muscarinic receptor antagonist
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Labeled Version(s)
25285Tiotropium-d3 (bromide)
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Product Categories

Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

Tiotropium (bromide)

Item No. 15773

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
CAS Number
136310-93-5
Synonyms
  • BA 679BR
Molecular Formula
C19H22NO4S2 • Br
Formula Weight
472.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
238 nm
SMILES
O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@H]3C[C@H]4[C@H]5[C@H](O5)[C@H]([N+]4(C)C)C3.[Br-]
InChi Code
InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11-,12-,13+,16-,17+;
InChi Key
DQHNAVOVODVIMG-FOGIBKMMSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $156

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    25 mg

    $475

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    50 mg

    $751

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    Product Description

    Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).1 It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Disse, B., Reichl, R., Speck, G., et al. Ba 679 BR, a novel long-acting anticholinergic bronchodilator. Life Sci. 52(5-6), 537-544 (1993).