An internal standard for the quantification of tiotropium
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Unlabeled Version(s)
15773Tiotropium (bromide)
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Tiotropium-d3 (bromide)

Item No. 25285

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9-methyl-9-(methyl-d3)-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, monobromide
CAS Number
1127226-56-5
Molecular Formula
C19H19D3NO4S2 • Br
Formula Weight
475.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly Soluble
SMILES
O=C(C(C1=CC=CS1)(O)C2=CC=CS2)O[C@H]3C[C@H]4[C@H]5[C@H](O5)[C@H]([N+]4(C([2H])([2H])[2H])C)C3.[Br-]
InChi Code
InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11-,12-,13+,16-,17+;/i1D3;/t11-,12-,13+,16-,17+,20?;
InChi Key
DQHNAVOVODVIMG-YQZQVDIVSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $169

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    1 mg

    $319

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    Product Description

    Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium (Item No. 15773) by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).1 It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Disse, B., Reichl, R., Speck, G., et al. Ba 679 BR, a novel long-acting anticholinergic bronchodilator. Life Sci. 52(5-6), 537-544 (1993).