An active metabolite of fluoxetine
Related Products
Analytical Standard(s)
35884Norfluoxetine (oxalate) (CRM)
Labeled Version(s)
34742Norfluoxetine-d5 (hydrochloride)
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Norfluoxetine (hydrochloride)

Item No. 15900

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γ-[4-(trifluoromethyl)phenoxy]-benzenepropanamine, monohydrochloride
CAS Number
57226-68-3
Synonyms
  • Desmethylfluoxetine
Molecular Formula
C16H16F3NO • HCl
Formula Weight
331.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
227, 264, 276 nm
SMILES
NCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.Cl
InChi Code
InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H
InChi Key
GMTWWEPBGGXBTO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1 It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2 Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM).1 It has been found in the tissues of fish exposed to wastewater effluent.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).

    2. Hiemke, C., and Härtter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol. Ther. 85(1), 11-28 (2000).

    3. Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al. Determination of select antidepressants in fish from an effluent-dominated stream. Environ. Toxicol. Chem. 24(2), 464-469 (2005).