An internal standard for the quantification of norfluoxetine
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Unlabeled Version(s)
15900Norfluoxetine (hydrochloride)
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Norfluoxetine-d5 (hydrochloride)

Item No. 34742

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
γ-[4-(trifluoromethyl)phenoxy]-benzenepropan-1,1,2,2,3-d5-amine, monohydrochloride
CAS Number
1185132-92-6
Synonyms
  • Desmethylfluoxetine-d5
Molecular Formula
C16H11D5F3NO • HCl
Formula Weight
336.8
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleDMSO: slightly soluble
SMILES
FC(F)(F)C(C=C1)=CC=C1OC(C2=CC=CC=C2)([2H])C([2H])([2H])C([2H])([2H])N.Cl
InChi Code
InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H/i10D2,11D2,15D;
InChi Key
GMTWWEPBGGXBTO-KDPCSTGBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $241

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    5 mg

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    Product Description

    Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine (Item No. 15900) by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1 It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2 Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM).1 It has been found in the tissues of fish exposed to wastewater effluent.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, D.T., Bymaster, F.P., Reid, L.R., et al. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain. Neuropsychopharmacology 8(4), 337-344 (1993).

    2. Hiemke, C., and Härtter, S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol. Ther. 85(1), 11-28 (2000).

    3. Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al. Determination of select antidepressants in fish from an effluent-dominated stream. Environ. Toxicol. Chem. 24(2), 464-469 (2005).